Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119035
Title: THE DEVELOPMENT AND FUNCTIONS OF MARGINAL ZONE B CELLS IN ATHEROSCLEROSIS
Authors: SOH YING, SERENA
Keywords: marginal zone B cells, atherosclerosis, iNKT cell anergy
Issue Date: 7-Aug-2014
Citation: SOH YING, SERENA (2014-08-07). THE DEVELOPMENT AND FUNCTIONS OF MARGINAL ZONE B CELLS IN ATHEROSCLEROSIS. ScholarBank@NUS Repository.
Abstract: ATHEROSCLEROSIS IS A CHRONIC INFLAMMATORY DISEASE CHARACTERIZED BY LEUKOCYTE INFILTRATION AND THE DEPOSITION OF LIPIDS IN THE ARTERIES. B LYMPHOCYTES HAVE BEEN FOUND IN ATHEROSCLEROTIC LESIONS BUT THEIR ROLE IN DISEASE DEVELOPMENT REMAINS UNCLEAR. IN THE PRESENT STUDY, WE FOUND THAT HYPERCHOLESTEROLEMIA WAS ASSOCIATED WITH AN EXPANSION OF THE MZ B CELL COMPARTMENT IN ATHEROSCLEROTIC APOE-/- MICE COMPARED TO AGE-MATCHED WT MICE AND THE INDUCTION OF DISEASE REGRESSION THROUGH THE TREATMENT OF ATHEROSCLEROTIC APOE-/- MICE WITH THE CHOLESTEROL LOWERING DRUG EZETIMIBE REVERSED THE EXPANSION OF MZ B CELLS. ANERGIC INKT CELLS WERE RESPONSIBLE FOR THE DECREASE IN APOPTOTIC CELL DEATH IN APOE-/- MICE AS THE INDUCTION OF INKT CELL ANERGY IN WT MICE RESULTED IN A TWO FOLD EXPANSION OF MZ B CELLS. INKT CELL-MEDIATED MZ B CELL DEATH WAS DEPENDENT ON IFN-G AS THE REINTRODUCTION OF FUNCTIONAL WT INKT CELLS BUT NOT IFN-G-/- INKT CELLS INTO APOE-/- MICE REVERSED MZ B CELL EXPANSION.
URI: http://scholarbank.nus.edu.sg/handle/10635/119035
Appears in Collections:Ph.D Theses (Open)

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