Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/118863
Title: Functional Role of Low Density Lipoprotein Receptor-Related Protein 5 and 6 in Alzheimer's Disease
Authors: ZHANG LUQI
Keywords: Alzheimer's disease; low density lipoprotein receptor-related protein 5/6; Wnt signaling; neurotoxicity; mitochondria; fusion and fission
Issue Date: 15-Aug-2014
Source: ZHANG LUQI (2014-08-15). Functional Role of Low Density Lipoprotein Receptor-Related Protein 5 and 6 in Alzheimer's Disease. ScholarBank@NUS Repository.
Abstract: The overall aim of this thesis is to understand the role of low density lipoprotein receptor-related protein (LRP) 5 and 6 in the pathogenesis of Alzheimer?s disease (AD). In the first hypothesis, we established the essential role of LRP5 and 6 in positively modulating Wnt signaling. Through upregulating Wnt pathway, LRP5 and 6 improves neuronal cell survival against hydrogen peroxide-induced cytotoxicity and reduces tau phosphorylation. In the second hypothesis, we discovered that the major AD genetic risk factor apolipoprotein (apo) E4 shifts the balanced mitochondrial dynamics towards fission process. This detrimental effect of apoE4 is carried out through binding to LRP5 and 6. Disruption of this interaction restores mitochondrial dynamics back to normal status. In summary, the findings in this thesis shed some light on the role of LRP5 and 6 in the pathogenesis of AD, which could offer a new therapeutic approach for the treatment and prevention of AD.
URI: http://scholarbank.nus.edu.sg/handle/10635/118863
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