Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/118856
Title: Use of Formic Acid/Formates as Hydrogen Source for Reactions
Authors: GAO YANXIU
Keywords: formic acid, formates, transfer hydrogenation, aldehydes, ketones, chemoselectivity
Issue Date: 23-Jan-2015
Citation: GAO YANXIU (2015-01-23). Use of Formic Acid/Formates as Hydrogen Source for Reactions. ScholarBank@NUS Repository.
Abstract: This thesis work investigated the reduction of carbonyl compounds to corresponding alcohols. The reduction was achieved via a catalytic transfer hydrogenation process using formic acid/formate as hydrogen source. The reduction of aromatic and aliphatic aldehydes was facile and occurred with 100 % yield over the Ru/AlO(OH) catalyst. In comparison, ketones were less readily reduced although moderate to excellent yield could be obtained after a longer reaction time. The unsaturated carbonyl compounds were successfully reduced to corresponding allylic alcohols over the amine-modified Ru/AlO(OH). Different amines were studied and the optimum amine was determined to be 3-(2-aminoethylamino)propyltrimethoxysilane. High yields of allylic alcohols, > 95 %, were obtained. The improvement in chemoselectivity to carbonyl groups was attributed to an increase in electron density at the Ru atom upon coordination with the amino groups.
URI: http://scholarbank.nus.edu.sg/handle/10635/118856
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