Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/118471
Title: CLINICAL, GENETICS AND MOLECULAR RISK FACTORS OF DENGUE SEVERITY
Authors: PANG JUNXIONG, VINCENT
Keywords: Dengue, Severity, Risk Factors, Early triage tool, Epidemiology,Public Health
Issue Date: 4-Aug-2014
Citation: PANG JUNXIONG, VINCENT (2014-08-04). CLINICAL, GENETICS AND MOLECULAR RISK FACTORS OF DENGUE SEVERITY. ScholarBank@NUS Repository.
Abstract: DENGUE CAUSES A SIGNIFICANT GLOBAL BURDEN OF DISEASE. THERE IS CURRENTLY NEITHER VACCINE NOR ANTIVIRAL THERAPY, BUT EARLY SUPPORTIVE TREATMENT REDUCES THE RISK OF DENGUE SEVERITY. HENCE, BESIDES EARLY DIAGNOSIS, EARLY PROGNOSIS OF DENGUE PATIENTS IS CRITICAL. AS BASELINE RISK FOR DENGUE SEVERITY, GENETIC RISK VARIANTS OF MICB AND PLCE1 GENES WERE SIGNIFICANTLY ASSOCIATED WITH DENGUE SHOCK SYNDROME. FURTHERMORE, DIABETES AND HYPERTENSION INCREASED THE RISK OF DENGUE HAEMORRHAGIC FEVER. AT EARLY DENGUE INFECTION, A RISK MODEL WITH CCL8, VPS13C RNA, UPAR PROTEIN AND PLATELETS POTENTIALLY ALLOWED EARLY IDENTIFICATION OF HIGH RISK PATIENTS WHOM WOULD REQUIRE STRICT MONITORING. AT FIRST PRESENTATION IN A TERTIARY HEALTHCARE SETTING, NEUTROPHIL, ALANINE AMINOTRANSFERASE AND UREA WERE PROPOSED AS A RISK MODEL FOR POTENTIAL ICU ADMISSION. APPLYING THESE EARLY RISK FACTORS AND MODELS AT DIFFERENT STAGES OF THE DISEASE MAY REDUCE SEVERITY THROUGH EARLY MONITORING AND PROMPT CLINICAL MANAGEMENT.
URI: http://scholarbank.nus.edu.sg/handle/10635/118471
Appears in Collections:Ph.D Theses (Open)

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