Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/118430
DC Field | Value | |
---|---|---|
dc.title | ZWITTERIONIC CATALYST MEDIATED MACROCYCLIZATION AND ITS APPLICATION TO BIOACTIVE MOLECULES SYNTHESES | |
dc.contributor.author | CHENG YI AN | |
dc.date.accessioned | 2015-01-12T18:00:15Z | |
dc.date.available | 2015-01-12T18:00:15Z | |
dc.date.issued | 2014-08-18 | |
dc.identifier.citation | CHENG YI AN (2014-08-18). ZWITTERIONIC CATALYST MEDIATED MACROCYCLIZATION AND ITS APPLICATION TO BIOACTIVE MOLECULES SYNTHESES. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/118430 | |
dc.description.abstract | HALOCYCLIZATION IS A POWERFUL METHODOLOGY TO CONSTRUCT A CYCLIC COMPOUND FROM A LINEAR ALKENE SUBSTRATE. THE APPLICATION OF HALOCYCLIZATION TO SYNTHESIZE MEDIUM (7- TO 9-MEMBERED) LACTONES AND LACTAMS IS, HOWEVER, HIGHLY UNCOMMON IN THE LITERATURE. AS THESE CYCLIC STRUCTURES COMMONLY OCCUR IN A VARIETY OF DRUGS AND BIOACTIVE MOLECULES, MILD AND EFFICIENT METHODS TO SYNTHESIZE SUCH COMPOUNDS WOULD BE HIGHLY DESIRABLE IN SYNTHETIC ORGANIC CHEMISTRY. THE WORK IN THIS THESIS SEEKS TO ADDRESS THE CURRENT GAP IN THE LITERATURE BY DETAILING NEWLY DEVELOPED ORGANOCATALYTIC METHODS TO ACCESS SUCH COMPOUNDS VIA HALOCYCLIZATION. THE AREAS OF FOCUS WILL BE ON (1) MEDIUM RING SIZE BROMOLACTONIZATION; (2) BROMOLACTAMIZATION TO GIVE A VARIETY OF LACTAM RING SIZES AND (3) ENANTIOSELECTIVE BROMOLACTAMIZATION. THE RESULTANT PRODUCTS CAN BE OBTAINED IN GOOD YIELDS AND/OR ENANTIOSELECTIVITIES. | |
dc.language.iso | en | |
dc.subject | Bromolactonization, Bromolactamization, Zwitterionic, Organocatalyst, Asymmetric, Halofunctionalization | |
dc.type | Thesis | |
dc.contributor.department | NUS GRAD SCH FOR INTEGRATIVE SCI & ENGG | |
dc.contributor.supervisor | WONG MING WAH, RICHARD | |
dc.contributor.supervisor | YEUNG YING YEUNG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
ChengYA_Main_Thesis.pdf | 5.5 MB | Adobe PDF | OPEN | None | View/Download | |
ChengYA_Appendix.pdf | 5.48 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.