Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/118284
Title: TOWARDS SELECTIVE CAPTURE OF BIOACTIVE LIPIDS USING SOLID PHASE APPROCHES
Authors: PRADEEP NARAYANASWAMY
Keywords: Lipidomics, sphingosine-1-phosphate (S1P), LCB-P, LCMS, Imidazolium polymer, mass spectrometry
Issue Date: 13-Aug-2014
Citation: PRADEEP NARAYANASWAMY (2014-08-13). TOWARDS SELECTIVE CAPTURE OF BIOACTIVE LIPIDS USING SOLID PHASE APPROCHES. ScholarBank@NUS Repository.
Abstract: Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to selectively capture phospho-monoester lipids by Imidazolium polymer and improved the detection of long-chain base phosphates (LCB-Ps eg: S1P), for their in-depth analysis of subspecies. Thirteen novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in various model organisms and also studied natural variation of LCB-Ps in Singaporean population. These findings have immediate relevance for our understanding of LCB-Ps biosynthesis, signaling and degradation.
URI: http://scholarbank.nus.edu.sg/handle/10635/118284
Appears in Collections:Ph.D Theses (Open)

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