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Title: Towards Identifying Novel Modulators and Targets for Alzheimer's Disease Therapy
Keywords: Azheimer's disease, glycogen syntahse kinase-3 beta, docosahexaenoic acid, tau phosphorylation, metabonomics, cholesterol
Issue Date: 11-Aug-2014
Source: BAHETY PRITI BALDEODAS (2014-08-11). Towards Identifying Novel Modulators and Targets for Alzheimer's Disease Therapy. ScholarBank@NUS Repository.
Abstract: The unavailability of effective therapeutic options for Alzheimer?s disease (AD) has made identification of novel modulators of the disease pathogenesis imperative. While the precise disease pathology is poorly understood, several approaches simultaneously targeting amyloid plaques, neurofibrillary tangles, inflammation and hypometabolism of neuronal cells have been proposed to provide effective therapeutic outcomes. The overall goal of this thesis is thus to identify and explore potential novel targets for therapeutic intervention in AD. We used two different approaches, wherein the first part, we explored the synergistic effect of dihydrofolate reductase inhibition in enhancing the neuroprotective and anti-inflammatory actions of glycogen synthase kinase-3? inhibitor. In the second part of the thesis we elucidated the molecular mechanisms of docosahexaenoic acid, a dietary supplement, in mitigating hypometabolic disturbances in AD cell models. Our results show that both these approaches may be further explored as a viable path to enhance the therapeutic outcome and delay the progression of injury in AD.
Appears in Collections:Ph.D Theses (Open)

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