Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/118108
Title: REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5
Authors: TANG PENG
Keywords: Obesity,Adipogenesis,Inflammation,hepatic steatosis,IRF3,MKP5
Issue Date: 21-Aug-2014
Source: TANG PENG (2014-08-21). REGULATION OF INFLAMMATION AND METABOLISM BY INTERFERON REGULATORY FACTOR 3 AND MAP KINASE PHOSPHATASE 5. ScholarBank@NUS Repository.
Abstract: OBESITY AND ASSOCIATED METABOLIC DISORDERS ARE MAJOR THREATS TO PUBLIC HEALTH. THE MECHANISMS THAT LEAD TO OBESITY-ASSOCIATED METABOLIC DISORDERS HAVE NOT BEEN WELL UNDERSTOOD. HERE, WE DISCOVERED TWO PROTEINS, INTERFERON REGULATORY FACTOR 3 (IRF3) AND MAPK PHOSPHATASE 5 (MKP5) PLAY IMPORTANT ROLES IN OBESITY-RELATED METABOLIC DISEASES. WE FOUND THAT IRF3 IS A NEGATIVE REGULATOR OF ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION THEREBY TO INHIBIT THE DEVELOPMENT OF OBESITY AND TYPE 2 DIABETES. MICE DEFICIENT IN IRF3 DEVELOPED OBESITY AND TYPE 2 DIABETES WHICH IS ASSOCIATED WITH INCREASED ADIPOGENESIS AND ADIPOSE TISSUE INFLAMMATION. FOR MKP5, WE FOUND IT PROTECTIVE IN THE DEVELOPMENT OF HEPATIC STEATOSIS. MICE DEFICIENT IN MKP5 DEVELOPED HEPATIC STEATOSIS, WHICH WAS ASSOCIATED WITH INCREASED P38 MAPK ACTIVITY IN THE LIVER. FURTHERMORE, MKP5 REGULATES THE EXPRESSION OF CIDEA AND FSP27, TWO GENES IMPORTANT FOR THE DEVELOPMENT OF HEPATIC STEATOSIS. THEREFORE, BOTH IRF3 AND MKP5 PLAYS COULD
URI: http://scholarbank.nus.edu.sg/handle/10635/118108
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Tang P. pdf.pdf4.64 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

98
checked on Feb 17, 2018

Download(s)

22
checked on Feb 17, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.