Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0091436
Title: Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques
Authors: Yaligar, J.
Gopalan, V.
Kiat, O.W.
Sugii, S.
Shui, G. 
Lam, B.D.
Henry, C.J.
Wenk, M.R.
Tai, E.S.
Velan, S.S.
Issue Date: 17-Mar-2014
Citation: Yaligar, J., Gopalan, V., Kiat, O.W., Sugii, S., Shui, G., Lam, B.D., Henry, C.J., Wenk, M.R., Tai, E.S., Velan, S.S. (2014-03-17). Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. PLoS ONE 9 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0091436
Abstract: Background & Aims: Dietary saturated fatty acids contribute to the development of fatty liver and have pathogenic link to systemic inflammation. We investigated the effects of dietary fat towards the pathogenesis of non-alcoholic fatty liver disease by longitudinal in vivo magnetic resonance spectroscopy (MRS) and in vitro liquid chromatography coupled with mass spectrometry (LC-MS). Methods: All measurements were performed on rats fed with high fat diet (HFD) and chow diet for twenty four weeks. Longitudinal MRS measurements were performed at the 12th, 18th and 24th weeks. Liver tissues were analyzed by LC-MS, histology and gene transcription studies after terminal in vivo experiments. Results: Liver fat content of HFD rats for all ages was significantly (P
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/117010
ISSN: 19326203
DOI: 10.1371/journal.pone.0091436
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2014-evaluation_dietary_effects_hepatic_lipids-published.pdf967.34 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

11
checked on Sep 20, 2018

WEB OF SCIENCETM
Citations

12
checked on Sep 10, 2018

Page view(s)

48
checked on Sep 21, 2018

Download(s)

7
checked on Sep 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.