Please use this identifier to cite or link to this item:
|Title:||Target cell movement in tumor and cardiovascular diseases based on the epithelial-mesenchymal transition concept|
|Citation:||Chua, K.-N., Poon, K.L., Lim, J., Sim, W.-J., Huang, R.Y.J., Thiery, J.P. (2011-07-18). Target cell movement in tumor and cardiovascular diseases based on the epithelial-mesenchymal transition concept. Advanced Drug Delivery Reviews 63 (8) : 558-567. ScholarBank@NUS Repository. https://doi.org/10.1016/j.addr.2011.02.003|
|Abstract:||Epithelial-mesenchymal transition (EMT) is a fundamental mechanism in development driving body plan formation. EMT describes a transition process wherein polarized epithelial cells lose their characteristics and acquire a mesenchymal phenotype. The apico-basal polarity of epithelial cells is replaced by a front-rear polarity in mesenchymal cells which favor cell-extracellular matrix than intercellular adhesion. These events serve as a prerequisite to the context-dependent migratory and invasive functions of mesenchymal cells. In solid tumors, carcinoma cells undergoing EMT not only invade and metastasize but also exhibit cancer stem cell-like properties, providing resistance to conventional and targeted therapies. In cardiovascular systems, epicardial cells engaged in EMT contribute to myocardial regeneration. Conversely, cardiovascular endothelial cells undergoing EMT cause cardiac fibrosis. Growing evidence has shed light on the potential development of novel therapeutics that target cell movement by applying the EMT concept, and this may provide new therapeutic strategies for the treatment of cancer and heart diseases. © 2011 Elsevier B.V.|
|Source Title:||Advanced Drug Delivery Reviews|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 9, 2018
WEB OF SCIENCETM
checked on Oct 31, 2018
checked on Oct 26, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.