Please use this identifier to cite or link to this item: https://doi.org/10.5732/cjc.012.10287
Title: Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy
Authors: Tan, J.
Yu, Q. 
Keywords: Drug resistance
MYC
PDK1
PI3K-mTOR pathway
Targeted therapy
Issue Date: 2013
Citation: Tan, J., Yu, Q. (2013). Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy. Chinese Journal of Cancer 32 (7) : 376-379. ScholarBank@NUS Repository. https://doi.org/10.5732/cjc.012.10287
Abstract: Deregulation of the phosphatidylinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human cancers and is a major driving force in tumorigenesis. Thus, small molecules targeting this pathway are under active development as anticancer therapeutics. Although small-molecule inhibitors of the PI3K-mTOR pathway have shown promising clinical efficacy against human cancers, the emergence of drug resistance may limit their success in the clinic. To date, several resistance mechanisms, including both PI3K-dependent and -independent mechanisms, have been described. Here, we summarize the current understanding of resistance mechanisms to PI3K-mTOR inhibitors and discuss potential strategies for overcoming resistance for potential clinical application. © Chinese Journal of Cancer.
Source Title: Chinese Journal of Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/116884
ISSN: 1000467X
DOI: 10.5732/cjc.012.10287
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