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|Title:||Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy|
|Citation:||Tan, J., Yu, Q. (2013). Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy. Chinese Journal of Cancer 32 (7) : 376-379. ScholarBank@NUS Repository. https://doi.org/10.5732/cjc.012.10287|
|Abstract:||Deregulation of the phosphatidylinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human cancers and is a major driving force in tumorigenesis. Thus, small molecules targeting this pathway are under active development as anticancer therapeutics. Although small-molecule inhibitors of the PI3K-mTOR pathway have shown promising clinical efficacy against human cancers, the emergence of drug resistance may limit their success in the clinic. To date, several resistance mechanisms, including both PI3K-dependent and -independent mechanisms, have been described. Here, we summarize the current understanding of resistance mechanisms to PI3K-mTOR inhibitors and discuss potential strategies for overcoming resistance for potential clinical application. © Chinese Journal of Cancer.|
|Source Title:||Chinese Journal of Cancer|
|Appears in Collections:||Staff Publications|
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