Please use this identifier to cite or link to this item: https://doi.org/10.1080/1521654031000153030
Title: Molecular mechanisms of neurodegeneration in Parkinson's disease: Clues from Mendelian syndromes
Authors: Lim, K.L. 
Lim, T.M. 
Keywords: α-synuclein
DJ-1
Oxidative stress
Parkin
Parkinson's disease
Proteasome
UCHL1
Issue Date: 1-Jun-2003
Citation: Lim, K.L., Lim, T.M. (2003-06-01). Molecular mechanisms of neurodegeneration in Parkinson's disease: Clues from Mendelian syndromes. IUBMB Life 55 (6) : 315-322. ScholarBank@NUS Repository. https://doi.org/10.1080/1521654031000153030
Abstract: The recent identification and characterization of gene products responsible for familial forms of Parkinson disease (PD) have provided significant insights into the pathogenesis of PD. Collectively, these studies point towards ubiquitin-proteasome system (UPS) dysfunction as an underlying mechanism responsible for dopaminergic cell death in PD. Emerging evidence further indicates a complex interplay between UPS derangements and other PD pathogenetic factors, all interwoven in an integrated network leading to dopaminergic cell death in PD. Taken together, these findings suggest that neuronal degeneration in PD is a result of a cascade of events, rather than a primary pathogenic event. Here, we review the clues uncovered from various Mendelian-inherited forms of PD that have helped shaped our understanding of the molecular mechanisms underlying PD pathogenesis.
Source Title: IUBMB Life
URI: http://scholarbank.nus.edu.sg/handle/10635/116883
ISSN: 15216543
DOI: 10.1080/1521654031000153030
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