Please use this identifier to cite or link to this item:
Title: Toward surface quantification of liver fibrosis progression
Authors: He, Y.
Raja, A.M.
Kang, C.H.
Peng, Q.
Xu, S.
So, P.T.C.
Tuo, X.
Rajapakse, J.C.
Trasti, S.
Welsch, R.
Tai, D.C.S.
Yu, H. 
Keywords: Bioimaging
Liver fibrosis
Medical optics
Second-harmonic generation
Issue Date: Sep-2010
Citation: He, Y., Raja, A.M., Kang, C.H., Peng, Q., Xu, S., So, P.T.C., Tuo, X., Rajapakse, J.C., Trasti, S., Welsch, R., Tai, D.C.S., Yu, H. (2010-09). Toward surface quantification of liver fibrosis progression. Journal of Biomedical Optics 15 (5) : -. ScholarBank@NUS Repository.
Abstract: Monitoring liver fibrosis progression by liver biopsy is important for certain treatment decisions, but repeated biopsy is invasive. We envision redefinition or elimination of liver biopsy with surface scanning of the liver with minimally invasive optical methods. This would be possible only if the information contained on or near liver surfaces accurately reflects the liver fibrosis progression in the liver interior. In our study, we acquired the second-harmonic generation and two-photon excitation fluorescence microscopy images of liver tissues from bile duct-ligated rat model of liver fibrosis. We extracted morphology-based features, such as total collagen, collagen in bile duct areas, bile duct proliferation, and areas occupied by remnant hepatocytes, and defined the capsule and subcapsular regions on the liver surface based on image analysis of features. We discovered a strong correlation between the liver fibrosis progression on the anterior surface and interior in both liver lobes, where biopsy is typically obtained. The posterior surface exhibits less correlation with the rest of the liver. Therefore, scanning the anterior liver surface would obtain similar information to that obtained from biopsy for monitoring liver fibrosis progression. © 2010 Society of Photo-Optical Instrumentation Engineers.
Source Title: Journal of Biomedical Optics
ISSN: 10833668
DOI: 10.1117/1.3490414
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Dec 4, 2018


checked on Dec 4, 2018

Page view(s)

checked on Dec 7, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.