Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.00379
Title: The Drosophila EAST protein associates with a nuclear remnant during mitosis and constrains chromosome mobility
Authors: Wasser, M. 
Chia, W.
Keywords: Chromosome congression
EAST
Meiosis
Mitosis
Nucleoskeleton
Issue Date: 1-May-2003
Source: Wasser, M., Chia, W. (2003-05-01). The Drosophila EAST protein associates with a nuclear remnant during mitosis and constrains chromosome mobility. Journal of Cell Science 116 (9) : 1733-1743. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.00379
Abstract: Drosophila EAST protein associates with an interior nonchromosomal compartment of the interphase nucleus. Because overexpression of east can dramatically alter nuclear architecture we investigated a potential role for EAST in changing chromosome organization during the cell cycle. Following nuclear envelope breakdown, EAST remains enriched in the mitotic remnant of the interphase nucleus until the onset of anaphase. Loss of east expression affects the accuracy of division cycles. In female meiosis, east mutations lead to abnormal segregation of nonexchange chromosomes. During the syncytial nuclear cycles, increased frequency of mitotic errors leads to the depletion of surface nuclei. In the post-syncytial cell cycles, abnormal congression of chromosomes in prometaphase delays the onset of anaphase. Loss of east expression also results in abnormal chromosome morphology in male meiosis. We propose that EAST constitutes a component of a nucleoskeleton that helps to constrain the mobility of chromosomes in interphase, mitosis and meiosis.
Source Title: Journal of Cell Science
URI: http://scholarbank.nus.edu.sg/handle/10635/116630
ISSN: 00219533
DOI: 10.1242/jcs.00379
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Feb 15, 2018

WEB OF SCIENCETM
Citations

12
checked on Feb 5, 2018

Page view(s)

35
checked on Feb 13, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.