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Title: Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation
Authors: Sugai, M.
Aoki, K.
Osato, M. 
Nambu, Y.
Ito, K.
Taketo, M.M.
Shimizu, A.
Issue Date: 1-Jun-2011
Citation: Sugai, M., Aoki, K., Osato, M., Nambu, Y., Ito, K., Taketo, M.M., Shimizu, A. (2011-06-01). Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. Journal of Immunology 186 (11) : 6515-6520. ScholarBank@NUS Repository.
Abstract: Inflammation is increasingly recognized as an essential component of tumorigenesis, which is promoted and suppressed by various T cell subsets acting in different ways. It was shown previously in Runx3-deficient mice that differentiation of CD8 Tand NK cells is perturbed. In this study, we show that Runx3 is also required for proper differentiation and function of regulatory T cells. In Runx3-deficient mice, T cells were unable to inhibit inflammation and to suppress tumor development. As expected, recombination activating gene 2-deficient mice bearing Runx3-deficient lymphocytes spontaneously developed colon tumors. However, tumor formation was completely blocked by transfer of either regulatory T cells or CD8 T cells derived from wild-type mice to mutant mice or by housing mutant mice in a specific pathogen-free condition. These results indicate that Runx3-deficient lymphocytes and microorganisms act together to induce inflammation and consequently induce the development of colon tumors. Copyright © 2011 by The American Association of Immunologists, Inc.
Source Title: Journal of Immunology
ISSN: 00221767
DOI: 10.4049/jimmunol.1001671
Appears in Collections:Staff Publications

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