Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/116478
Title: Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms
Authors: Carter, D.A. 
Keywords: Adrenergic receptor
Fos
Immediate-early gene
Jun
NGFI-A
Pineal
Issue Date: Nov-1992
Citation: Carter, D.A. (1992-11). Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms. Molecular Brain Research 16 (1-2) : 111-118. ScholarBank@NUS Repository.
Abstract: The products of the cellular immediate-early genes (IEGs) are thought to act as messengers in the coupling of trans-synaptic stimuli with altered neuronal gene expression. However, the manner in which neurotransmission specifies particular responses through the IEGs is undefined. In this report, mRNA and transcription analysis of a precisely-timed, physiological IEG response illustrates how an IEG signal may be organized through differential neurotransmitter receptor activation. The nocturnal pattern of IEG expression in the rat pineal gland has been shown to be differentially regulated through post-synaptic adrenergic receptors. Induction of the c-fos gene is primarily mediated through α1-receptors, whereas the coordinately regulated jun-B gene exhibits dual regulation through α1- and β-receptors. A simultaneous repression of c-jun expression is partly mediated through a β-receptor mechanism. In vitro analysis of IEGs in cultured pineal glands has confirmed the receptor-specific link between adrenergic neurotransmission and IEG induction. The pineal is a unique neurodocrine model in which the characteristics and function of the IEG third messenger system may be defined. © 1992.
Source Title: Molecular Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/116478
ISSN: 0169328X
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

24
checked on Sep 28, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.