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|Title:||Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms|
|Citation:||Carter, D.A. (1992-11). Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms. Molecular Brain Research 16 (1-2) : 111-118. ScholarBank@NUS Repository.|
|Abstract:||The products of the cellular immediate-early genes (IEGs) are thought to act as messengers in the coupling of trans-synaptic stimuli with altered neuronal gene expression. However, the manner in which neurotransmission specifies particular responses through the IEGs is undefined. In this report, mRNA and transcription analysis of a precisely-timed, physiological IEG response illustrates how an IEG signal may be organized through differential neurotransmitter receptor activation. The nocturnal pattern of IEG expression in the rat pineal gland has been shown to be differentially regulated through post-synaptic adrenergic receptors. Induction of the c-fos gene is primarily mediated through α1-receptors, whereas the coordinately regulated jun-B gene exhibits dual regulation through α1- and β-receptors. A simultaneous repression of c-jun expression is partly mediated through a β-receptor mechanism. In vitro analysis of IEGs in cultured pineal glands has confirmed the receptor-specific link between adrenergic neurotransmission and IEG induction. The pineal is a unique neurodocrine model in which the characteristics and function of the IEG third messenger system may be defined. © 1992.|
|Source Title:||Molecular Brain Research|
|Appears in Collections:||Staff Publications|
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