Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuint.2012.08.001
Title: CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus
Authors: Liu, J.X.
Cao, X.
Liu, Y.
Tang, F.R. 
Keywords: CCL28
Chemokine
Hippocampus
Status epilepticus
Issue Date: Dec-2012
Citation: Liu, J.X., Cao, X., Liu, Y., Tang, F.R. (2012-12). CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. Neurochemistry International 61 (7) : 1094-1101. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuint.2012.08.001
Abstract: The present study showed a wide presence of CCL28 in mouse CNS, including cerebral, cerebellum, brain stem and spinal cord. In hippocampus, the expression of CCL28 at both mRNA and protein level was clarified. The CCL28 expression was mainly localized in pyramidal cells of CA area, granular cells of dentate gyrus and some interneurons in CA area and hilus. Double-labelling immunocytochemistry revealed that most of calbindin, calretinin and parvalbumin immunopositive neurons expressed CCL28. During and after pilocarpine induced status epilepticus (SE), a down-regulated expression of CCL28 in hippocampal interneurons in the CA1 area and in the hilus of the dentate gyrus was demonstrated. The present study may, therefore provide evidence that CCL28 may have a novel role in CNS and may be involved in the loss of hippocampal interneurons, and subsequent disinhibition of pyramidal neurons. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Neurochemistry International
URI: http://scholarbank.nus.edu.sg/handle/10635/116249
ISSN: 01970186
DOI: 10.1016/j.neuint.2012.08.001
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Aug 14, 2018

WEB OF SCIENCETM
Citations

3
checked on Aug 14, 2018

Page view(s)

28
checked on Aug 3, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.