Please use this identifier to cite or link to this item: https://doi.org/10.4161/cam.25139
Title: α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing
Authors: Dufour, S.
Mège, R.-M.
Thiery, J.P. 
Keywords: Adhesion
Cadherin
Catenin
Cytoskeleton
Force
Mechanosensing
Strength
Vinculin
Issue Date: Jul-2013
Citation: Dufour, S., Mège, R.-M., Thiery, J.P. (2013-07). α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing. Cell Adhesion and Migration 7 (4) : 345-350. ScholarBank@NUS Repository. https://doi.org/10.4161/cam.25139
Abstract: Classical cadherins play a crucial role in establishing intercellular adhesion, regulating cortical tension, and maintaining mechanical coupling between cells. The mechanosensitive regulation of intercellular adhesion strengthening depends on the recruitment of adhesion complexes at adhesion sites and their anchoring to the actin cytoskeleton. Thus, the molecular mechanisms coupling cadherin-associated complexes to the actin cytoskeleton are actively being studied, with a particular focus on α-catenin and vinculin. We have recently addressed the role of these proteins by analyzing the consequences of their depletion and the expression of α-catenin mutants in the formation and strengthening of cadherin-mediated adhesions. We have used the dual pipette assay to measure the forces required to separate cell doublets formed in suspension. In this commentary, we briefly summarize the current knowledge on the role of α-catenin and vinculin in cadherin- actin cytoskeletal interactions. These data shed light on the tension-dependent contribution of α-catenin and vinculin in a mechanoresponsive complex that promotes the connection between cadherin and the actin cytoskeleton and their requirement in the development of adhesion strengthening. © 2013 Landes Bioscience.
Source Title: Cell Adhesion and Migration
URI: http://scholarbank.nus.edu.sg/handle/10635/116181
ISSN: 19336918
DOI: 10.4161/cam.25139
Appears in Collections:Staff Publications

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