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Title: Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model
Authors: Bard-Chapeau, E.A.
Nguyen, A.-T.
Rust, A.G.
Sayadi, A.
Lee, P.
Chua, B.Q.
New, L.-S. 
De Jong, J.
Ward, J.M.
Chin, C.K.Y.
Chew, V.
Toh, H.C.
Abastado, J.-P.
Benoukraf, T. 
Soong, R.
Bard, F.A.
Dupuy, A.J.
Johnson, R.L.
Radda, G.K.
Chan, E.C.Y. 
Wessels, L.F.A.
Adams, D.J.
Jenkins, N.A.
Copeland, N.G.
Issue Date: Jan-2014
Source: Bard-Chapeau, E.A., Nguyen, A.-T., Rust, A.G., Sayadi, A., Lee, P., Chua, B.Q., New, L.-S., De Jong, J., Ward, J.M., Chin, C.K.Y., Chew, V., Toh, H.C., Abastado, J.-P., Benoukraf, T., Soong, R., Bard, F.A., Dupuy, A.J., Johnson, R.L., Radda, G.K., Chan, E.C.Y., Wessels, L.F.A., Adams, D.J., Jenkins, N.A., Copeland, N.G. (2014-01). Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (1) : 24-32. ScholarBank@NUS Repository.
Abstract: The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC. © 2014 Nature America, Inc.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.2847
Appears in Collections:Staff Publications

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