Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.b.30395
Title: Study on the drug release property of cholesteryl end-functionalized poly(ε-caprolactone) microspheres
Authors: Yu, L.
Zhang, H.
Cheng, S.-X.
Zhuo, R.-X.
Li, H. 
Keywords: Biomimetic
Degradation
Drug delivery/release
Enzyme(s)
Matrix
Polymerization
Issue Date: Apr-2006
Citation: Yu, L., Zhang, H., Cheng, S.-X., Zhuo, R.-X., Li, H. (2006-04). Study on the drug release property of cholesteryl end-functionalized poly(ε-caprolactone) microspheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials 77 (1) : 39-46. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.b.30395
Abstract: End-functionalized poly/oligo(ε-caprolactone)s were synthesized through the ring-opening polymerization of ε-caprolactone initiated by cholesterol with a hydroxyl group. Using the end-functionalized poly/oligo(ε-caprolactone)s with different molecular weights, the microsphere drug delivery systems were fabricated using a convenient melting-emulsion method. The drug release properties of microspheres were investigated with the presence of an enzyme, Pseudomonas cepacia lipase, as well as in the absence of the enzyme. The release profiles can be fitted nicely by the classical empirical exponential expression. Under the hydrolytic condition, the drug release is mainly controlled by Fickian diffusion, and the high molecular weight of the matrix results in a slower drug release rate. Under the enzymatic condition, the drug release is dominated by combined degradation and diffusion mechanism, and the high molecular weight sample exhibits a faster release rate that is mainly caused by the higher degradation rate of the sample with lower cholesteryl moiety content. © 2005 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/115954
ISSN: 00219304
DOI: 10.1002/jbm.b.30395
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