Please use this identifier to cite or link to this item:
|Title:||Study on the drug release property of cholesteryl end-functionalized poly(ε-caprolactone) microspheres|
|Citation:||Yu, L., Zhang, H., Cheng, S.-X., Zhuo, R.-X., Li, H. (2006-04). Study on the drug release property of cholesteryl end-functionalized poly(ε-caprolactone) microspheres. Journal of Biomedical Materials Research - Part B Applied Biomaterials 77 (1) : 39-46. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.b.30395|
|Abstract:||End-functionalized poly/oligo(ε-caprolactone)s were synthesized through the ring-opening polymerization of ε-caprolactone initiated by cholesterol with a hydroxyl group. Using the end-functionalized poly/oligo(ε-caprolactone)s with different molecular weights, the microsphere drug delivery systems were fabricated using a convenient melting-emulsion method. The drug release properties of microspheres were investigated with the presence of an enzyme, Pseudomonas cepacia lipase, as well as in the absence of the enzyme. The release profiles can be fitted nicely by the classical empirical exponential expression. Under the hydrolytic condition, the drug release is mainly controlled by Fickian diffusion, and the high molecular weight of the matrix results in a slower drug release rate. Under the enzymatic condition, the drug release is dominated by combined degradation and diffusion mechanism, and the high molecular weight sample exhibits a faster release rate that is mainly caused by the higher degradation rate of the sample with lower cholesteryl moiety content. © 2005 Wiley Periodicals, Inc.|
|Source Title:||Journal of Biomedical Materials Research - Part B Applied Biomaterials|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 17, 2018
WEB OF SCIENCETM
checked on May 16, 2018
checked on May 4, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.