Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/115938
Title: Solid-phase synthesis of β-keto esters via sequential baylis - Hillman and heck reactions
Authors: Kulkarni, B.A. 
Ganesan, A. 
Issue Date: 1999
Source: Kulkarni, B.A.,Ganesan, A. (1999). Solid-phase synthesis of β-keto esters via sequential baylis - Hillman and heck reactions. Journal of Combinatorial Chemistry 1 (5) : 373-378. ScholarBank@NUS Repository.
Abstract: Acrylic acid was immobilized on polystyrene - Wang resin, followed by Baylis - Hillman reaction with aldehydes using DABCO as catalyst. Addition of 1 equiv of lanthanum(III) trifluoromethanesulfonate was found to improve yields, as in solution phase. After the Baylis - Hillman step, Heck reaction with aryl halides resulted in α-substituted β-keto esters, which were cleaved from the resin by acid hydrolysis with concomitant decarboxylation to afford aryl ketone products. Overall yields of 0-49% were obtained with 26 examples.
Source Title: Journal of Combinatorial Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/115938
ISSN: 15204766
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

17
checked on Jan 21, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.