Please use this identifier to cite or link to this item: https://doi.org/10.1097/JTO.0b013e31826baf83
Title: Targeting ROS1 with anaplastic lymphoma kinase inhibitors: A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer
Authors: Chin, L.P.
Soo, R.A. 
Soong, R. 
Ou, S.-H.I.
Keywords: Anaplastic lymphoma kinase inhibitors
Crizotinib
Non-small-cell lung cancer
ROS1
Targeted therapy
Issue Date: Nov-2012
Citation: Chin, L.P., Soo, R.A., Soong, R., Ou, S.-H.I. (2012-11). Targeting ROS1 with anaplastic lymphoma kinase inhibitors: A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer. Journal of Thoracic Oncology 7 (11) : 1625-1630. ScholarBank@NUS Repository. https://doi.org/10.1097/JTO.0b013e31826baf83
Abstract: Chromosomal rearrangements involving the ROS1 receptor tyrosine kinase have been described in a variety of human malignancies including non-small-cell lung cancer (NSCLC), cholangiocarcinoma and glioblastoma multiforme. Recently, clinicopathologic characteristics of c-ros oncogene 1, receptor tyrosine kinase (ROS1)-rearranged NSCLC patients have been described. Furthermore, anaplastic lymphoma kinase inhibitor, novel class of drugs targeting this tyrosine kinase receptor is currently under clinical trial in this molecular subset of NSCLC patients. This review will focus on the current knowledge of ROS1 rearrangements in NSCLC, methods to detect ROS1 rearrangement, and targeting ROS1-rearranged NSCLC patients with anaplastic lymphoma kinase inhibitors. Copyright © 2012 by the International Association for the Study of Lung Cancer.
Source Title: Journal of Thoracic Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/115550
ISSN: 15560864
DOI: 10.1097/JTO.0b013e31826baf83
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