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Title: Expansion mechanisms and functional divergence of the glutathione S-transferase family in sorghum and other higher plants
Authors: Chi, Y.
Cheng, Y.
Vanitha, J.
Kumar, N.
Ramamoorthy, R.
Ramachandran, S. 
Jiang, S.-Y.
Keywords: abiotic stress
biotic stress
comparative genomics
functional divergence
glutathione transferase
Issue Date: Feb-2011
Citation: Chi, Y., Cheng, Y., Vanitha, J., Kumar, N., Ramamoorthy, R., Ramachandran, S., Jiang, S.-Y. (2011-02). Expansion mechanisms and functional divergence of the glutathione S-transferase family in sorghum and other higher plants. DNA Research 18 (1) : 1-16. ScholarBank@NUS Repository.
Abstract: Glutathione S-transferases (GSTs) exist in various eukaryotes and function in detoxification of xenobiotics and in response to abiotic and biotic stresses. We have carried out a genome-wide survey of this gene family in 10 plant genomes. Our data show that tandem duplication has been regarded as the major expansion mechanism and both monocot and dicot plants may have practiced different expansion and evolutionary history. Non-synonymous substitutions per site (Ka) and synonymous substitutions per site (Ks) analyses showed that N- and C-terminal functional domains of GSTs (GST-N and GST-C) seem to have evolved under a strong purifying selection (Ka/Ks < 1) under different selective pressures. Differential evolutionary rates between GST-N and GST-C and high degree of expression divergence have been regarded as the major drivers for the retention of duplicated genes and the adaptability to various stresses. Expression profiling also indicated that the gene family plays a role not only in stress-related biological processes but also in the sugar-signalling pathway. Our survey provides additional annotation of the plant GST gene family and advance the understanding of plant GSTs in lineage-specific expansion and species diversification. © 2010 The Author.
Source Title: DNA Research
ISSN: 13402838
DOI: 10.1093/dnares/dsq031
Appears in Collections:Staff Publications

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