Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/115011
Title: Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
Authors: Buescher, M. 
Yeo, S.L. 
Udolph, G.
Zavortink, M.
Yang, X. 
Tear, G.
Chia, W. 
Keywords: Asymmetric cell division
Cell fate determinant
Neural progenitor
Issue Date: 15-Jun-1998
Source: Buescher, M.,Yeo, S.L.,Udolph, G.,Zavortink, M.,Yang, X.,Tear, G.,Chia, W. (1998-06-15). Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. Genes and Development 12 (12) : 1858-1870. ScholarBank@NUS Repository.
Abstract: Asymmetric cell division is a widespread mechanism in developing tissues that leads to the generation of cell diversity. In the embryonic central nervous system of Drosophila melanogaster, secondary precursor cells - ganglion mother cells (GMCs) - divide and produce postmitotic neurons that take on different cell fates. In this study, we show that binary fate decision of two pairs of sibling neurons is accomplished through the interplay of Notch (N) signaling and the intrinsic fate determinant Numb. We show that GMCs have apical-basal polarity and Numb localization and the orientation of division are coordinated to segregate Numb to only one sibling cell. The correct positioning of Numb and the proper orientation of division require Inscuteable (Insc). Loss of insc results in the generation of equivalent sibling cells. Our results provide evidence that sibling neuron fate decision is nonstochastic and normally depends on the presence of Numb in one of the two siblings. Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells.
Source Title: Genes and Development
URI: http://scholarbank.nus.edu.sg/handle/10635/115011
ISSN: 08909369
Appears in Collections:Staff Publications

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