Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/114790
Title: FIBROUS SCAFFOLDS FOR TISSUE ENGINEERING
Authors: TOH KAH CHIN JERRY
Keywords: tissue engineering, polyelectrolyte complex, ROMP, adipose, vascularization, 3D patterning
Issue Date: 26-May-2014
Citation: TOH KAH CHIN JERRY (2014-05-26). FIBROUS SCAFFOLDS FOR TISSUE ENGINEERING. ScholarBank@NUS Repository.
Abstract: INTERFACIAL POLYELECTROLYTE COMPLEX (IPC) FIBERS HAVE PROVEN TO BE A ROBUST AND CELL-FRIENDLY BIOLOGICAL SCAFFOLD FOR PROTEINS AND LIVING CELLS DUE TO THEIR AQUEOUS, MILD PH FORMATION AT ROOM TEMPERATURE. THEY ARE SUITABLE FOR SUPPORTING HEPATOCYTES, CHONDROCYTES, MESENCHYMAL STEM CELLS AND EMBRYONIC STEM CELLS AMONGST OTHERS. ALSO, ENCAPSULATED PROTEINS REMAIN BIOLOGICALLY ACTIVE WITHIN THE FIBER SCAFFOLDS. THIS THESIS EXPANDS UPON THE SCOPE OF IPC FIBERS AND THEIR APPLICATIONS AS A BIOLOGICAL SCAFFOLD FOR TISSUE ENGINEERING. IPC FIBER SCAFFOLDS HAVE THE DRAWBACKS OF BEING HARD TO HANDLE, BEING DIFFICULT TO SPATIALLY ORGANIZE AND HAVING A LIMITED SUBSTRATE SCOPE. BY DEVELOPING NEW FABRICATION METHODS AND MATERIALS, THIS THESIS AIMS TO ADDRESS THESE ISSUES AND INCREASE THE APPLICABILITY OF IPC FIBER SCAFFOLDS IN TISSUE ENGINEERING.
URI: http://scholarbank.nus.edu.sg/handle/10635/114790
Appears in Collections:Ph.D Theses (Open)

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Title page and contents - FINALIZED.pdf156.01 kBAdobe PDF

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Chapter 1 - Background and Motivation PT Ref - FINALIZED.pdf144.54 kBAdobe PDF

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Chapter 2 - Patterned fiber assembled tissue constructs - FINALIZED.pdf952.57 kBAdobe PDF

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Chapter 3- A Patterned Pre-vascularised Scaffold for Adipose Tissue Engineering - FINALIZED.pdf994.06 kBAdobe PDF

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Chapter 4 - ROMP-based synthetic interfacial polyelectrolyte complex fibers - FINALIZED.pdf943.16 kBAdobe PDF

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Chapter 5 - Conclusions and Future Work - FINALIZED.pdf81.34 kBAdobe PDF

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Appendix.pdf802.2 kBAdobe PDF

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