Please use this identifier to cite or link to this item:
|Title:||Near-infrared Raman spectroscopy for colonic cancer diagnosis|
|Authors:||Huang, Z. |
Near-infrared Raman spectroscopy
|Source:||Huang, Z.,Zheng, W.,Colin, S. (2005). Near-infrared Raman spectroscopy for colonic cancer diagnosis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5862 : 4-. ScholarBank@NUS Repository.|
|Abstract:||This study evaluated the diagnostic ability of near-infrared (NIR) Raman spectroscopy for identifying the malignant tumors from normal and benign tissues in the colon. In this work, a rapid NIR Raman system was utilized for tissue Raman studies. A total of 105 colonie specimens were used for Raman studies, including 41 normals, 18 polyps (benign), and 46 malignant tumors (22 of moderately differentiated adenocarcinomas and 24 of poorly differentiated adenocarcinomas). The results showed that high-quality Raman spectra in the 800-1800 cm-1 range can be acquired from human colonie tissues in vitro, and Raman spectra differed significantly between normal and malignant tumor tissue. The diagnostic algorithm using the Raman intensity ratios of I1085/1445 vs. I1002/1445 can yield a diagnostic sensitivity of 100%and specificity of 96.6% for differentiation between between normal, benign and malignant colonic tissue. This work demonstrates that NIR Raman spectroscopy technique has a significant potential for the noninvasive diagnosis of colon cancer in vivo based on the evaluation of changes of molecular vibrations of biomolecules in tissue. © 2005 SPIE-OSA.|
|Source Title:||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 18, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.