Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0014063
Title: Storm: A general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts
Authors: Wang, Z. 
Matsudaira, P. 
Gong, Z. 
Issue Date: 2010
Citation: Wang, Z., Matsudaira, P., Gong, Z. (2010). Storm: A general model to determine the number and adaptive changes of epithelial stem cells in teleost, murine and human intestinal tracts. PLoS ONE 5 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0014063
Abstract: Intestinal stem cells play a pivotal role in the epithelial tissue renewal, homeostasis and cancer development. The lack of a general marker for intestinal stem cells across species has hampered analysis of stem cell number in different species and their adaptive changes upon intestinal lesions or during development of cancer. Here a two-dimensional model, named STORM, has been developed to address this issue. By optimizing epithelium renewal dynamics, the model examines the epithelial stem cell number by taking experimental input information regarding epithelium proliferation and differentiation. As the results suggest, there are 2.0-4.1 epithelial stem cells on each pocket section of zebrafish intestine, 2.0-4.1 stem cells on each crypt section of murine small intestine and 1.8-3.5 stem cells on each crypt section of human duodenum. The model is able to provide quick results for stem cell number and its adaptive changes, which is not easy to measure through experiments. Its general applicability to different species makes it a valuable tool for analysis of intestinal stem cells under various pathological conditions. © 2010 Wang et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/114391
ISSN: 19326203
DOI: 10.1371/journal.pone.0014063
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2010-storm_general_model_determine_number_adaptive-pub.pdf423.92 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

7
checked on Oct 17, 2018

WEB OF SCIENCETM
Citations

8
checked on Oct 10, 2018

Page view(s)

61
checked on Oct 12, 2018

Download(s)

7
checked on Oct 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.