Please use this identifier to cite or link to this item: https://doi.org/10.2174/157015905774322525
Title: Agonists and antagonists of metabotropic glutamate receptors: Anticonvulsants and antiepileptogenic agents?
Authors: Tang, F.R. 
Issue Date: Oct-2005
Source: Tang, F.R. (2005-10). Agonists and antagonists of metabotropic glutamate receptors: Anticonvulsants and antiepileptogenic agents?. Current Neuropharmacology 3 (4) : 299-307. ScholarBank@NUS Repository. https://doi.org/10.2174/157015905774322525
Abstract: Anticonvulsant and neuroprotective effects of agonist and antagonist of metabotropic glutamate receptors (mGluRs) have been known for more than 10 years from multiple studies. However, it is not certain whether these candidate drugs are also antiepileptic and antiepileptogenic, as few studies included the chronic stages to determine whether spontaneous recurrent seizures could be prevented or stopped. Even in the acute stage, differences in experimental design such as timing and route of administration of candidate drugs, age, species and strain of experimental animal and experimental model make it difficult to determine the anticonvulsant and neuroprotective effects of each candidate drug. This paper, reviews in vivo neuropharmacological studies on agonsists and antagonists of mGluRs in different seizure and epilepsy models in last more than ten years. By combining with our neuropharmacological studies on the effect of mGluR agonists and antagonists in the mouse pilocarpine model of temporal lobe epilepsy, an ideal model for future development of mGluR agonists and antagonists as antiepileptogenic drugs will be proposed. © 2005 Bentham Science Publishers Ltd.
Source Title: Current Neuropharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/113777
ISSN: 1570159X
DOI: 10.2174/157015905774322525
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Jan 22, 2018

Page view(s)

53
checked on Jan 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.