Plasma activity of contact coagulation factors in patients with IgA nephritis
Tan, C.C. Lee, G.S.L. Lee, E.J.C. Woo, K.T.
Lee, G.S.L.
Lee, E.J.C.
Woo, K.T.
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Alternative Title
Abstract
Intraglomerular coagulation, initiated by the local activation of contact coagulation factors, has been suggested as one possible factor causing glomerular injury in IgA nephritis. The plasma activity of factor XII, prekallikrein and high molecular weight (HMW) kininogen were measured in 24 patients with biopsy-proven IgA nephritis and in 123 normal controls, using an activated partial thromboplastin time assay with the appropriate factor-deficient plasma as substrate. IgA patients had significantly lower plasma activity of factor XII (45.5% ± 28.3% against 80.7% ± 31.8%; mean ± standard deviation, P
Keywords
Factor XII, Glomerular injury, High molecular weight kininogen, Intraglomerular coagulation, Prekallikrein
Source Title
Annals of the Academy of Medicine Singapore
Publisher
Series/Report No.
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Date
1996-03
DOI
Type
Article