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https://doi.org/10.1097/01.ASN.0000077347.27669.5C
DC Field | Value | |
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dc.title | Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus | |
dc.contributor.author | Araki, S.-I. | |
dc.contributor.author | Ng, D.P.K. | |
dc.contributor.author | Krolewski, B. | |
dc.contributor.author | Wyrwicz, L. | |
dc.contributor.author | Rogus, J.J. | |
dc.contributor.author | Canani, L. | |
dc.contributor.author | Makita, Y. | |
dc.contributor.author | Haneda, M. | |
dc.contributor.author | Warram, J.H. | |
dc.contributor.author | Krolewski, A.S. | |
dc.date.accessioned | 2014-12-01T06:55:17Z | |
dc.date.available | 2014-12-01T06:55:17Z | |
dc.date.issued | 2003-08-01 | |
dc.identifier.citation | Araki, S.-I., Ng, D.P.K., Krolewski, B., Wyrwicz, L., Rogus, J.J., Canani, L., Makita, Y., Haneda, M., Warram, J.H., Krolewski, A.S. (2003-08-01). Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus. Journal of the American Society of Nephrology 14 (8) : 2015-2024. ScholarBank@NUS Repository. https://doi.org/10.1097/01.ASN.0000077347.27669.5C | |
dc.identifier.issn | 10466673 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/113509 | |
dc.description.abstract | Abnormal activation of protein kinase C-β isoforms in the diabetic state has been implicated in the development of diabetic nephropathy. It is thus plausible that DNA sequence differences in the protein kinase C-β1 gene (PRKCB1), which encodes both βI and βII isoforms, may influence susceptibility to nephropathy. Nine single-nucleotide polymorphisms (SNP) in PRKCB1 were tested for association with diabetic nephropathy in type I diabetes mellitus, by using both case-control and family-study designs. Allele and genotype distributions of two SNP in the promoter (-1504C/T and -546C/G) differed significantly between case patients and control patients (P < 0.05). These associations were particularly strong with diabetes mellitus duration of | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1097/01.ASN.0000077347.27669.5C | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | COMMUNITY,OCCUPATIONAL & FAMILY MEDICINE | |
dc.description.doi | 10.1097/01.ASN.0000077347.27669.5C | |
dc.description.sourcetitle | Journal of the American Society of Nephrology | |
dc.description.volume | 14 | |
dc.description.issue | 8 | |
dc.description.page | 2015-2024 | |
dc.description.coden | JASNE | |
dc.identifier.isiut | 000184352600007 | |
Appears in Collections: | Staff Publications |
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