Please use this identifier to cite or link to this item: https://doi.org/10.1097/01.ASN.0000077347.27669.5C
Title: Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus
Authors: Araki, S.-I.
Ng, D.P.K. 
Krolewski, B.
Wyrwicz, L.
Rogus, J.J.
Canani, L.
Makita, Y.
Haneda, M.
Warram, J.H.
Krolewski, A.S.
Issue Date: 1-Aug-2003
Citation: Araki, S.-I., Ng, D.P.K., Krolewski, B., Wyrwicz, L., Rogus, J.J., Canani, L., Makita, Y., Haneda, M., Warram, J.H., Krolewski, A.S. (2003-08-01). Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus. Journal of the American Society of Nephrology 14 (8) : 2015-2024. ScholarBank@NUS Repository. https://doi.org/10.1097/01.ASN.0000077347.27669.5C
Abstract: Abnormal activation of protein kinase C-β isoforms in the diabetic state has been implicated in the development of diabetic nephropathy. It is thus plausible that DNA sequence differences in the protein kinase C-β1 gene (PRKCB1), which encodes both βI and βII isoforms, may influence susceptibility to nephropathy. Nine single-nucleotide polymorphisms (SNP) in PRKCB1 were tested for association with diabetic nephropathy in type I diabetes mellitus, by using both case-control and family-study designs. Allele and genotype distributions of two SNP in the promoter (-1504C/T and -546C/G) differed significantly between case patients and control patients (P < 0.05). These associations were particularly strong with diabetes mellitus duration of
Source Title: Journal of the American Society of Nephrology
URI: http://scholarbank.nus.edu.sg/handle/10635/113509
ISSN: 10466673
DOI: 10.1097/01.ASN.0000077347.27669.5C
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