Please use this identifier to cite or link to this item:
Title: Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus
Authors: Araki, S.-I.
Ng, D.P.K. 
Krolewski, B.
Wyrwicz, L.
Rogus, J.J.
Canani, L.
Makita, Y.
Haneda, M.
Warram, J.H.
Krolewski, A.S.
Issue Date: 1-Aug-2003
Citation: Araki, S.-I., Ng, D.P.K., Krolewski, B., Wyrwicz, L., Rogus, J.J., Canani, L., Makita, Y., Haneda, M., Warram, J.H., Krolewski, A.S. (2003-08-01). Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-β1 (PRKCB1) gene locus. Journal of the American Society of Nephrology 14 (8) : 2015-2024. ScholarBank@NUS Repository.
Abstract: Abnormal activation of protein kinase C-β isoforms in the diabetic state has been implicated in the development of diabetic nephropathy. It is thus plausible that DNA sequence differences in the protein kinase C-β1 gene (PRKCB1), which encodes both βI and βII isoforms, may influence susceptibility to nephropathy. Nine single-nucleotide polymorphisms (SNP) in PRKCB1 were tested for association with diabetic nephropathy in type I diabetes mellitus, by using both case-control and family-study designs. Allele and genotype distributions of two SNP in the promoter (-1504C/T and -546C/G) differed significantly between case patients and control patients (P < 0.05). These associations were particularly strong with diabetes mellitus duration of
Source Title: Journal of the American Society of Nephrology
ISSN: 10466673
DOI: 10.1097/01.ASN.0000077347.27669.5C
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jun 14, 2018


checked on May 7, 2018

Page view(s)

checked on May 18, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.