Please use this identifier to cite or link to this item: https://doi.org/10.1158/1055-9965.EPI-04-0864
Title: Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States
Authors: Cheng, I.
Yu, M.C.
Koh, W.-P. 
Pike, M.C.
Kolonel, L.N.
Henderson, B.E.
Stram, D.O.
Issue Date: Jul-2005
Citation: Cheng, I., Yu, M.C., Koh, W.-P., Pike, M.C., Kolonel, L.N., Henderson, B.E., Stram, D.O. (2005-07). Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States. Cancer Epidemiology Biomarkers and Prevention 14 (7) : 1692-1696. ScholarBank@NUS Repository. https://doi.org/10.1158/1055-9965.EPI-04-0864
Abstract: Prostate cancer incidence rates markedly vary between countries. The highest rates of prostate cancer are observed in Western countries such as the United States, whereas the lowest rates are seen in Asian countries such as Singapore. To gain an understanding of the difference in prostate cancer burden between low-risk and high-risk populations, we examined serum prostate-specific antigen (PSA) levels among Singapore-Chinese men (n = 315) from the Singapore Chinese Health Study and African-American (n = 440), U.S. White (n = 355), U.S. Latino (n = 523), and Japanese-American (n = 349) men from the Hawaii-Los Angeles Multiethnic Cohort Study. All men had no history of prostate cancer at the time of blood draw. PSA measurements were assayed by one centralized diagnostic facility. Testosterone and 3α-androstanediol glucuronide levels were examined in a subsample of men. Scheffe's multiple comparison tests were used to evaluate differences in PSA and hormone levels between groups. PSA levels among the Singapore-Chinese (geometric mean = 1.43 ng/mL) were similar to that of African-Americans (1.46 ng/mL), U.S. Whites (1.28 ng/mL), and Japanese-Americans (1.22 ng/mL) and significantly higher than U.S. Latinos (1.18 ng/mL; P = 0.038). Although there was a strong correlation (R2 = 0.89) between PSA levels and U.S. ethnic group-specific prostate cancer incidence rates before PSA screening (1983-1987), the levels among the Singapore-Chinese completely failed to relate to their low incidence rate. Testosterone and 3α-androstanediol glucuronide levels did not reflect racial/ ethnic patterns of disease. Our results highlight a potentially large group of Singapore-Chinese men with undiagnosed prostate cancer. Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population. Copyright © 2005 American Association for Cancer Research.
Source Title: Cancer Epidemiology Biomarkers and Prevention
URI: http://scholarbank.nus.edu.sg/handle/10635/113407
ISSN: 10559965
DOI: 10.1158/1055-9965.EPI-04-0864
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Sep 12, 2018

WEB OF SCIENCETM
Citations

17
checked on Sep 12, 2018

Page view(s)

28
checked on Aug 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.