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Title: Effects of Anti-Malaria Drug Artesunate in the Treatment of Rhinovirus-Induced Asthma Exacerbation
Authors: TAO LIN
Keywords: anti-malarial, artesunate, rhinovirus-induced asthma exacerbation
Issue Date: 24-Jan-2014
Source: TAO LIN (2014-01-24). Effects of Anti-Malaria Drug Artesunate in the Treatment of Rhinovirus-Induced Asthma Exacerbation. ScholarBank@NUS Repository.
Abstract: Rhinovirus causes the majority of virus-induced asthma exacerbations. The purpose of this study was to investigate the inflammatory mechanisms underlying this exacerbation phenomenon. Firstly, we demonstrated that RV-1B exacerbated the Th2 response in HDM-induced allergic asthma. Secondly, we tested the effects of anti-malarial drug Artesunate in the treatment of RV-induced asthma exacerbation. Artesunate was administrated after RV infection via i.p. route Compared with DMSO treatment group, artesunate significantly inhibited rhinovirus?induced exacerbation in total inflammatory cell count, eosinophil count and lymphocyte count. Artesunate also significantly inhibited rhinovirus-induced exacerbation in IL-4, IL-5, IL-13, IP-10 and Muc5AC mRNA production. Meanwhile, artesunate singnificantly inhibited rhinovirus-induced total IgE secretion and airway hyperresponsiveness. At last, we also found that artesunate significantly reduced the binding activity of NF-?B. Artesunate attenuated the exacerbation of RV on asthma, and our findings implicated a potential value of artesunate in the treatment of rhinovirus-induced asthma exacerbation.
Appears in Collections:Ph.D Theses (Open)

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