Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0054834
DC Field | Value | |
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dc.title | A Novel Trans Conformation of Ligand-Free Calmodulin | |
dc.contributor.author | Kumar, V. | |
dc.contributor.author | Chichili, V.P.R. | |
dc.contributor.author | Tang, X. | |
dc.contributor.author | Sivaraman, J. | |
dc.date.accessioned | 2014-11-28T09:12:18Z | |
dc.date.available | 2014-11-28T09:12:18Z | |
dc.date.issued | 2013-01-29 | |
dc.identifier.citation | Kumar, V., Chichili, V.P.R., Tang, X., Sivaraman, J. (2013-01-29). A Novel Trans Conformation of Ligand-Free Calmodulin. PLoS ONE 8 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0054834 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/113123 | |
dc.description.abstract | Calmodulin (CaM) is a highly conserved eukaryotic protein that binds specifically to more than 100 target proteins in response to calcium (Ca2+) signal. CaM adopts a considerable degree of structural plasticity to accomplish this physiological role; however, the nature and extent of this plasticity remain to be fully understood. Here, we report the crystal structure of a novel trans conformation of ligand-free CaM where the relative disposition of two lobes of CaM is different, a conformation to-date not reported. While no major structural changes were observed in the independent N- and C-lobes as compared with previously reported structures of Ca2+/CaM, the central helix was tilted by ~90° at Arg75. This is the first crystal structure of CaM to show a drastic conformational change in the central helix, and reveals one of several possible conformations of CaM to engage with its binding partner. © 2013 Kumar et al. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0054834 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MECHANOBIOLOGY INSTITUTE | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1371/journal.pone.0054834 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 8 | |
dc.description.issue | 1 | |
dc.description.page | - | |
dc.identifier.isiut | 000315483200002 | |
Appears in Collections: | Staff Publications Elements |
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