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Title: The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain
Authors: Wang, X.
Korzh, V. 
Gong, Z. 
Keywords: Basic domain
Basic helix-loop-helix
Issue Date: 5-Jun-2002
Citation: Wang, X., Korzh, V., Gong, Z. (2002-06-05). The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain. FEBS Letters 520 (1-3) : 139-144. ScholarBank@NUS Repository.
Abstract: In zebrafish, the basic helix-loop-helix (bHLH) gene neuroD specifies distinct neurons in the spinal cord. A preliminary experiment indicated that a related bHLH gene, ndr1a, normally expressed only in the olfactory organ in late embryos, also functions as neuroD to induce ectopic formation of spinal cord neurons in early embryos after introduction of its mRNA into early embryos. To define the functional specificity of these bHLH proteins, several mutant forms with selected point mutations in the basic domain were constructed and tested for inducing sensory neurons in the spinal cord. Our data indicate that the functional specificity of NeuroD to define sensory neurons is mainly due to a single residue (asparagine 11) in its basic domain. © 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Source Title: FEBS Letters
ISSN: 00145793
DOI: 10.1016/S0014-5793(02)02809-0
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