Please use this identifier to cite or link to this item: https://doi.org/10.1021/nn102738c
Title: Thin films of functionalized multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation
Authors: Nayak, T.R.
Jian, L. 
Phua, L.C.
Ho, H.K. 
Ren, Y.
Pastorin, G. 
Keywords: bone
carbon nanotubes
cell differentiation
functionalization
mesenchymal stem cells
osteogenesis
Issue Date: 28-Dec-2010
Source: Nayak, T.R., Jian, L., Phua, L.C., Ho, H.K., Ren, Y., Pastorin, G. (2010-12-28). Thin films of functionalized multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation. ACS Nano 4 (12) : 7717-7725. ScholarBank@NUS Repository. https://doi.org/10.1021/nn102738c
Abstract: In the field of regenerative medicine, human mesenchymal stem cells envisage extremely promising applications, due to their ability to differentiate into a wide range of connective tissue species on the basis of the substrate on which they grow. For the first time ever reported, we investigated the effects of a thin film of pegylated multiwalled carbon nanotubes spray dried onto preheated coverslips in terms of their ability to influence human mesenchymal stem cells' proliferation, morphology, and final differentiation into osteoblasts. Results clearly indicated that the homogeneous layer of functionalized nanotubes did not show any cytotoxicity and accelerated cell differentiation to a higher extent than carboxylated nanotubes or uncoated coverslips, by creating a more viable microenvironment for stem cells. Interestingly, cell differentiation occurred even in the absence of additional biochemical inducing agents, as evidenced by multiple independent criteria at the transcriptional, protein expression, and functional levels. Taken together, these findings suggest that functionalized carbon nanotubes represent a suitable scaffold toward a very selective differentiation into bone. © 2010 American Chemical Society.
Source Title: ACS Nano
URI: http://scholarbank.nus.edu.sg/handle/10635/112657
ISSN: 19360851
DOI: 10.1021/nn102738c
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