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|Title:||Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants|
De La Peña, A.
|Citation:||Willis, B.A., Zhang, W., Ayan-Oshodi, M., Lowe, S.L., Annes, W.F., Sirois, P.J., Friedrich, S., De La Peña, A. (2012-06). Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants. Journal of Clinical Pharmacology 52 (6) : 904-913. ScholarBank@NUS Repository. https://doi.org/10.1177/0091270011407195|
|Abstract:||Semagacestat, γ-secretase inhibitor, reduces formation of amyloid beta peptide. Two single-dose (140 mg), openlabel, randomized, 3-period, crossover studies evaluated the effect of formulation, food, and time of dosing on the pharmacokinetics and pharmacodynamics of semagacestat in healthy participants. The first study (n = 14) compared tablet to capsules. For all formulations, the median time to maximum plasma concentration (tmax) was generally 1.0 hour. Plasma elimination was rapid, with a half-life of approximately 2.5 hours. Tablet form II bioavailability (F) relative to capsule was approximately 100% (F = 1.03 [90% confidence interval (CI), 0.96-1.10]). In the second study, participants (n = 27) received semagacestat either fed or fasting in the morning or fasting in the evening. No significant change in exposure (AUC0-8 [area under the concentration-time curve from 0 to infinity] ratio = 1.02, [90% CI, 0.990-1.05]) occurred with food, whereas maximum plasma concentration (Cmax) declined approximately 15%, and median tmax was delayed to 1.5 hours. Time of dosing made no significant difference in AUC0-8, Cmax, or tmax (AUC0-8 ratio 1.01, [90% CI, 0.975-1.04]). No clinically significant safety concerns occurred in either study. Accordingly, semagacestat may be dosed without regard to formulation, food, or time of administration. © 2012 The Author(s).|
|Source Title:||Journal of Clinical Pharmacology|
|Appears in Collections:||Staff Publications|
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