Please use this identifier to cite or link to this item: https://doi.org/10.1016/B978-0-12-396456-4.00013-4
Title: Role of the JNK Pathway in human diseases
Authors: Sabapathy, K. 
Keywords: Apoptosis
c-Jun
Disease
Inhibitors
JNK
Phosphorylation
Substrates
Issue Date: 2012
Citation: Sabapathy, K. (2012). Role of the JNK Pathway in human diseases. Progress in Molecular Biology and Translational Science 106 : 145-169. ScholarBank@NUS Repository. https://doi.org/10.1016/B978-0-12-396456-4.00013-4
Abstract: The c-Jun-NH 2-terminal kinase (JNK) signaling pathway plays a critical role in regulating cell fate, being implicated in a multitude of diseases ranging from cancer to neurological and immunological/inflammatory conditions. Not surprisingly, therefore, it has been sought after for therapeutic intervention, and its inhibition has been shown to ameliorate many pathological conditions in experimental systems, paving the way for initial clinical trials. However, the fundamental problem in fully harnessing the potential provided by the JNK pathway has been the lack of specificity, due to the multiple JNK forms that are involved in multiple cellular processes in various cell types. Moreover, lack of sufficient knowledge of all JNK-interacting proteins and substrates has also hindered progress. This review will therefore focus on the role of the JNKs in human diseases and appraise the efforts to inhibit JNK signaling to ameliorate disease conditions, assessing potential challenges and providing insights into possible future directions to efficiently target this pathway for therapeutic use. © 2012 Elsevier Inc.
Source Title: Progress in Molecular Biology and Translational Science
URI: http://scholarbank.nus.edu.sg/handle/10635/112061
ISSN: 18771173
DOI: 10.1016/B978-0-12-396456-4.00013-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

56
checked on Jun 21, 2018

WEB OF SCIENCETM
Citations

49
checked on May 1, 2018

Page view(s)

36
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.