Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/112039
DC Field | Value | |
---|---|---|
dc.title | Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo | |
dc.contributor.author | Sun, Q. | |
dc.contributor.author | Bahri, S. | |
dc.contributor.author | Schmid, A. | |
dc.contributor.author | Chia, W. | |
dc.contributor.author | Zinn, K. | |
dc.date.accessioned | 2014-11-28T02:52:28Z | |
dc.date.available | 2014-11-28T02:52:28Z | |
dc.date.issued | 2000-02 | |
dc.identifier.citation | Sun, Q.,Bahri, S.,Schmid, A.,Chia, W.,Zinn, K. (2000-02). Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo. Development 127 (4) : 801-812. ScholarBank@NUS Repository. | |
dc.identifier.issn | 09501991 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/112039 | |
dc.description.abstract | Neural receptor-linked protein tyrosine phosphatases (RPTPs) are required for guidance of motoneuron and photoreceptor growth cones in Drosophila. These phosphatases have not been implicated in growth cone responses to specific guidance cues, however, so it is unknown which aspects of axonal pathfinding are controlled by their activities. Three RPTPs, known as DLAR, DPTP69D, and DPTP99A, have been genetically characterized thus far. Here we report the isolation of mutations in the fourth neural RPTP, DPTP10D. The analysis of double mutant phenotypes shows that DPTP10D and DPTP69D are necessary for repulsion of growth cones from the midline of the embryonic central nervous system. Repulsion is thought to be triggered by binding of the secreted protein Slit, which is expressed by midline glia, to Roundabout (Robo) receptors on growth cones. Robo repulsion is downregulated by the Commissureless (Comm) protein, allowing axons to cross the midline. Here we show that the Rptp mutations genetically interact with robo, slit and comm. The nature of these interactions suggests that DPTP10D and DPTP69D are positive regulators of Slit/Roundabout repulsive signaling. We also show that elimination of all four neural RPTPs converts most noncrossing longitudinal pathways into commissures that cross the midline, indicating that tyrosine phosphorylation controls the manner in which growth cones respond to midline signals. | |
dc.source | Scopus | |
dc.subject | Axon guidance | |
dc.subject | Commissureless | |
dc.subject | Drosophila melanogaster | |
dc.subject | Drosophila neurogenetics | |
dc.subject | Growth cone repulsion | |
dc.subject | Neural development | |
dc.subject | Receptor tyrosine phosphatase | |
dc.subject | Roundabout | |
dc.subject | Tyrosine phosphorylation | |
dc.type | Article | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.contributor.department | DEAN'S OFFICE (MEDICINE) | |
dc.description.sourcetitle | Development | |
dc.description.volume | 127 | |
dc.description.issue | 4 | |
dc.description.page | 801-812 | |
dc.description.coden | DEVPE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.