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|Title:||Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components|
|Source:||Carter, D.A. (1993-09-15). Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components. European Journal of Pharmacology: Molecular Pharmacology 247 (1) : 97-100. ScholarBank@NUS Repository.|
|Abstract:||One component of the nocturnal changes in cellular immediate-early gene expression in the rat pineal gland is a decrease in c-jun expression, mediated through ß-adrenoceptors. An in vitro study of the intracellular mechanisms which control c-jun expression has now shown that a norepinephrine-induced increase in c-jun mRNA levels in organ-cultured pineals is differentially modulated by protein kinase inhibitors; N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA-1004) potentiated the response; however, in the presence of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a significant decrease in c-jun mRNA was found. Treatment with HA-1004 alone elevated the level of c-jun mRNA, H-7 alone was without effect. Forskolin together with 3-isobutyl-1-methylxanthine suppressed c-jun, whereas phorbol 12,13-dibutyrate raised c-jun mRNA levels. The results demonstrate opposing pathways for c-jun regulation in the pineal gland, and indicate that the nocturnal attenuation of c-jun expression involves selective activation of a negative pathway which may be linked to cAMP. © 1993.|
|Source Title:||European Journal of Pharmacology: Molecular Pharmacology|
|Appears in Collections:||Staff Publications|
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