Please use this identifier to cite or link to this item:
|Title:||Identification of a Plasmodium berghei antigen sharing common features with P. Falciparum and P. Chabaudi parasitophorous-vacuole membrane antigens|
|Authors:||Tan, T.M.C. |
|Citation:||Tan, T.M.C., Goh, K.L., Binh, L.N., Ting, R.C.Y., Kara, U.A.K. (1996). Identification of a Plasmodium berghei antigen sharing common features with P. Falciparum and P. Chabaudi parasitophorous-vacuole membrane antigens. Parasitology Research 82 (2) : 130-135. ScholarBank@NUS Repository. https://doi.org/10.1007/s004360050083|
|Abstract:||On the basis of immunological cross-reactivity, we identified a 43-kDa Plasmodium berghei antigen with homology to the exp-1 antigen from P. falciparium. The P. berghei antigen was recognized by an antibody directed against an epitope on the C-terminus of the P. falciparum exp-1 protein. This antigen is localized on the surface of the parasite and shares peptide sequence homology with the P. chabudi antigen Ag3008. To investigate further the role of the P. berghei antigen, we designed antisense phosphorothioate oligodeoxynucleotides (PS oligos) complementary to sequences of the exp-1 mRNA from P. falciparum. The PS oligos were capable of inhibiting the development of P. falciparum in vitro by 47%. In vivo, experiments in mice showed that the same PS oligos had the potential to extend the life span of mice infected with P. berghei by a factor of 2-4. The immunological cross-reactivity and the antisense inhibition of P. berghei parasite development in vivo indicate that this antigen may be a homologue of exp-1 from P. falciparum that has functional importance for parasite survival.|
|Source Title:||Parasitology Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 19, 2018
WEB OF SCIENCETM
checked on Jun 11, 2018
checked on Jun 8, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.