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|Title:||Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family|
|Authors:||Dick, T. |
|Citation:||Dick, T., Bahri, S.M., Chia, W. (1997-10-15). Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family. Gene 199 (1-2) : 139-143. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1119(97)00359-4|
|Abstract:||We report the nuclear cloning, chromosome mapping and developmental pattern of a putative serine/threonine protein phosphates 2C(PP2C), DPP2C1, from Drosophila melanogaster. The 6-kb transcript of this first Drosophila PP2C gene encodes a 1,428-aa deduced protein. The DPP2C1 protein contains a ≃ 330-aa PP2C-like catalytic domain flanked by extensive N- and C-terminal sequences showing no similarities to other PP2Cs. The dpp2c1 gene maps to 4E1-2 on the X chromosome, 1.5kb upstream of the ddlc1 gene. Northern blot analyses showed that dpp2c1 transcription is developmentally regulated, accumulating maximally during early (0-6h) and late (12-24h) embryogenesis. The presented molecular characterisation provides the basis for a genetic dissection of DPP2C1 function.|
|Appears in Collections:||Staff Publications|
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