Please use this identifier to cite or link to this item:
Title: c-Jun promotes cellular survival by suppression of PTEN
Authors: Hettinger, K.
Vikhanskaya, F.
Poh, M.K.
Lee, M.K.
de Belle, I.
Zhang, J.-T.
Reddy, S.A.G.
Sabapathy, K. 
Issue Date: Feb-2007
Citation: Hettinger, K., Vikhanskaya, F., Poh, M.K., Lee, M.K., de Belle, I., Zhang, J.-T., Reddy, S.A.G., Sabapathy, K. (2007-02). c-Jun promotes cellular survival by suppression of PTEN. Cell Death and Differentiation 14 (2) : 218-229. ScholarBank@NUS Repository.
Abstract: Activation of c-Jun, a component of the AP-1 family of transcription factors, leads to either promotion or prevention of apoptosis. However, the molecular determinants of c-Jun-mediated cell survival are still unclear. We show here that inducible expression of c-Jun promotes cellular survival by negatively regulating the expression of the tumor-suppressor PTEN, resulting in the concomitant activation of the Akt survival pathway. Consistently, c-jun-/- fibroblasts, which are sensitive to nutrient deprivation, and human cell lines in which c-Jun expression is silenced, express elevated levels of PTEN. siRNA-mediated silencing of PTEN resulted in the reduction of cell-death owing to c-Jun deficiency. c-Jun was found to suppress PTEN expression by binding to a variant AP-1 site found in the 5′ upstream sequences of PTEN promoter. Finally, an inverse correlation between c-Jun and PTEN levels was apparent in a panel of human tumor cell lines, independent of their p53 status. Together, the data demonstrate that c-Jun contributes to the promotion of cellular survival by regulating the expression of PTEN.
Source Title: Cell Death and Differentiation
ISSN: 13509047
DOI: 10.1038/sj.cdd.4401946
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 21, 2019


checked on Mar 12, 2019

Page view(s)

checked on Mar 22, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.