Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/110951
Title: FUNCTIONAL ANALYSIS OF ATRX, A HOMOLOGUE OF HISTONE H3.3 CHROMATINREMODELING FACTOR, IN ARABIDOPSIS THALIANA
Authors: WANG HAIFENG
Keywords: Epigenetics, Chromatin, Histone variants, Histone Chaperones, Chromatin-remodeling factors, Histone modifications
Issue Date: 12-Aug-2014
Citation: WANG HAIFENG (2014-08-12). FUNCTIONAL ANALYSIS OF ATRX, A HOMOLOGUE OF HISTONE H3.3 CHROMATINREMODELING FACTOR, IN ARABIDOPSIS THALIANA. ScholarBank@NUS Repository.
Abstract: IN MAMMALIANS, REGULATION OF HISTONE H3.3 DISTRIBUTION IS CLOSELY RELATED TO GENE EXPRESSION AND THE UNDERLINE MECHANISMS HAVEN BEEN SHOWN TO HAVE AT LEAST TWO INDEPENDENT HISTONE H3.3 DEPOSITION PATHWAYS MEDIATED BY HISTONE CHAPERONES: 1) THE HIRA DEPENDENT PATHWAY AT TRANSCRIPTION START SITE (TSS) AND GENE BODIES OF TRANSCRIPTIONALLY ACTIVE LOCI; 2) THE ATRX/DAXX DEPENDENT PATHWAY AT PERICENTRIC HETEROCHROMATIN AND TELOMERES. SIMILAR TO MAMMALIANS, IN PLANTS, THE DEPOSITION OF H3.3 VARIANT IS ALSO STRONGLY CORRELATED WITH ACTIVE GENES AT EUCHROMATIN IN A TRANSCRIPTION DEPENDENT MANNER. HOWEVER, THE UNDERLINE MECHANISMS OF HISTONE H3.3 INCORPORATION IN PLANTS ARE STILL UNKNOWN. SINCE HIRA AND ATRX (BUT NOT DAXX) ARE CONSERVED IN PLANTS, HERE, WE APPLIED A REVERSE GENETIC METHOD TO STUDY FUNCTIONS OF THESE TWO HISTONE H3.3 ASSOCIATED PROTEIN CANDIDATES USING A PLANT MODEL SYSTEM, ARABIDOPSIS THALIANA. MY RESULTS, WHICH WERE FOCUSED ON ATRX, SHOW THAT, UNLIKE IN MAMMALIANS, ARABIDOPSIS
URI: http://scholarbank.nus.edu.sg/handle/10635/110951
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
WangHF.pdf26.2 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

132
checked on Oct 5, 2018

Download(s)

28
checked on Oct 5, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.