Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(03)00732-5
Title: Application of diaza-18-crown-6-capped β-cyclodextrin bonded silica particles as chiral stationary phases for ultrahigh pressure capillary liquid chromatography
Authors: Gong, Y. 
Xiang, Y.
Yue, B.
Xue, G.
Bradshaw, J.S.
Lee, H.K. 
Lee, M.L.
Keywords: Chiral stationary phases, LC
Diaza-18-crown-6-capped β-cyclodextrin bonded silica
Enantiomeric separations
Issue Date: 20-Jun-2003
Citation: Gong, Y., Xiang, Y., Yue, B., Xue, G., Bradshaw, J.S., Lee, H.K., Lee, M.L. (2003-06-20). Application of diaza-18-crown-6-capped β-cyclodextrin bonded silica particles as chiral stationary phases for ultrahigh pressure capillary liquid chromatography. Journal of Chromatography A 1002 (1-2) : 63-70. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(03)00732-5
Abstract: Two bonded chiral stationary phases (CSPs), 8-aminoquinoline-2-ylmethyl- and 8-aminoquinoline-7-ylmethyl-diaza-18-crown-6-capped [3-(2-O-β-cyclodextrin)-2-hydroxypropoxy]propylsilyl silica particles (non-porous, 1.5 μm), have been prepared and evaluated using capillary liquid chromatography at high pressures (≥8000 p.s.i.). High column efficiency (up to 400 000 plates m-1) was achieved for chiral separations. These CSPs with two recognition sites, i.e. substituted-diaza-18-crown-6 and β-cyclodextrin combined with high chromatographic efficiency provide good resolution of a variety of enantiomers and positional isomers in relatively short times under reversed-phase conditions. After inclusion of a Ni (II) ion from the mobile phase, the positively charged crown ether-capped β-cyclodextrin facilitates specific static, dipolar, and host-guest complexation interactions with solutes. © 2003 Elsevier Science B.V. All rights reserved.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/110840
ISSN: 00219673
DOI: 10.1016/S0021-9673(03)00732-5
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