Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.dld.2013.09.025
Title: Immunohistochemical analysis of metaplastic non-goblet columnar lined oesophagus shows phenotypic similarities to Barrett's oesophagus: A study in an Asian population
Authors: Srivastava, S. 
Liew, M.S.
McKeon, F.
Xian, W.
Yeoh, K.G.
Ho, K.Y.
Teh, M.
Keywords: Barrett's oesophagus
Claudin 3
Columnar lined oesophagus
MUC4
Oesophageal adenocarcinoma
Issue Date: Feb-2014
Citation: Srivastava, S., Liew, M.S., McKeon, F., Xian, W., Yeoh, K.G., Ho, K.Y., Teh, M. (2014-02). Immunohistochemical analysis of metaplastic non-goblet columnar lined oesophagus shows phenotypic similarities to Barrett's oesophagus: A study in an Asian population. Digestive and Liver Disease 46 (2) : 170-175. ScholarBank@NUS Repository. https://doi.org/10.1016/j.dld.2013.09.025
Abstract: Background: Barrett's oesophagus is a premalignant condition, predisposing to oesophageal adenocarcinoma. However, some adenocarcinoma may arise in columnar lined oesophagus without goblet cells. Our aim was to evaluate the biological properties of non-goblet columnar lined oesophagus only and elucidate its relationship with Barrett's oesophagus and associated neoplasia. Methods: Endoscopic biopsies from patients with Barrett's oesophagus (n= 30), non-goblet columnar lined oesophagus (n= 14), Barrett's oesophagus associated high grade dysplasia (n= 6) and adenocarcinoma (n= 4) were selected. Immunostaining for villin, claudin 3 and MUC4 was performed. Statistical analysis was performed and a p value
Source Title: Digestive and Liver Disease
URI: http://scholarbank.nus.edu.sg/handle/10635/110748
ISSN: 15908658
DOI: 10.1016/j.dld.2013.09.025
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