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Title: C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
Authors: Ye, M.
Zhang, H.
Amabile, G.
Yang, H.
Staber, P.B.
Zhang, P.
Levantini, E.
Alberich-Jordà, M.
Zhang, J.
Kawasaki, A. 
Tenen, D.G.
Issue Date: Apr-2013
Source: Ye, M., Zhang, H., Amabile, G., Yang, H., Staber, P.B., Zhang, P., Levantini, E., Alberich-Jordà, M., Zhang, J., Kawasaki, A., Tenen, D.G. (2013-04). C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nature Cell Biology 15 (4) : 385-394. ScholarBank@NUS Repository.
Abstract: In blood, the transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver haematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here, using an inducible knockout model we found that C/EBPa-deficient adult HSCs underwent a pronounced increase in number with enhanced proliferation, characteristics resembling fetal liver HSCs. Consistently, transcription profiling of C/EBPa-deficient HSCs revealed a gene expression program similar to fetal liver HSCs. Moreover, we observed that age-specific Cebpa expression correlated with its inhibitory effect on the HSC cell cycle. Mechanistically we identified N-Myc as a downstream target of C/EBPa, and loss of C/EBPa resulted in de-repression of N-Myc. Our data establish C/EBPa as a central determinant in the switch from fetal to adult HSCs. © 2013 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Cell Biology
ISSN: 14657392
DOI: 10.1038/ncb2698
Appears in Collections:Staff Publications

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