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https://doi.org/10.1126/scitranslmed.3002743
Title: | Defending male fertility | Authors: | Rozen, S. | Issue Date: | 20-Jul-2011 | Citation: | Rozen, S. (2011-07-20). Defending male fertility. Science Translational Medicine 3 (92) : -. ScholarBank@NUS Repository. https://doi.org/10.1126/scitranslmed.3002743 | Abstract: | An estimated 10 to 15% of couples suffer from infertility, and many treatment decisions rely on trial and error. In this issue of Science Translational Medicine, Tollner and colleagues provide strong evidence from a human genetics study that a common variant in the beta defensin 126 gene, the "del" variant, can reduce male fertility substantially. In addition, they show a plausible mechanism for reduced fertility: Sperm from del/del homozygotes lack an important component of their glycoprotein coat and have difficulty penetrating a surrogate for cervical mucus. If replicated in future studies, these findings promise to guide choices about the timing and type of assisted reproduction interventions - and further hint at the possibility of treating sperm from del/del homozygotes to promote fertility. | Source Title: | Science Translational Medicine | URI: | http://scholarbank.nus.edu.sg/handle/10635/110696 | ISSN: | 19466234 | DOI: | 10.1126/scitranslmed.3002743 |
Appears in Collections: | Staff Publications |
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