Please use this identifier to cite or link to this item: https://doi.org/10.1109/MEMSYS.2012.6170300
Title: A study of cancer cell metastasis using microfluidic transmigration device
Authors: Fu, Y.
Vandongen, A.M.J. 
Bourouina, T.
Park, W.T.
Je, M.Y.
Tsai, J.M.
Kwong, D.L.
Liu, A.Q.
Issue Date: 2012
Citation: Fu, Y.,Vandongen, A.M.J.,Bourouina, T.,Park, W.T.,Je, M.Y.,Tsai, J.M.,Kwong, D.L.,Liu, A.Q. (2012). A study of cancer cell metastasis using microfluidic transmigration device. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) : 773-776. ScholarBank@NUS Repository. https://doi.org/10.1109/MEMSYS.2012.6170300
Abstract: Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy. © 2012 IEEE.
Source Title: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
URI: http://scholarbank.nus.edu.sg/handle/10635/110663
ISBN: 9781467303248
ISSN: 10846999
DOI: 10.1109/MEMSYS.2012.6170300
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