Please use this identifier to cite or link to this item: https://doi.org/10.1212/WNL.0b013e3181b9c8ce
Title: Three-dimensional MR volumetric analysis of the posterior fossa CSF space in hemifacial spasm
Authors: Chan, L.-L.
Ng, K.-M.
Fook-Chong, S.
Lo, Y.-L.
Tan, E.-K. 
Issue Date: Sep-2009
Citation: Chan, L.-L., Ng, K.-M., Fook-Chong, S., Lo, Y.-L., Tan, E.-K. (2009-09). Three-dimensional MR volumetric analysis of the posterior fossa CSF space in hemifacial spasm. Neurology 73 (13) : 1054-1057. ScholarBank@NUS Repository. https://doi.org/10.1212/WNL.0b013e3181b9c8ce
Abstract: BACKGROUND: We hypothesize that a smaller posterior fossa (PF) CSF space may be a risk factor for hemifacial spasm (HFS). OBJECTIVE: We conducted a case-control 3-dimensional magnetic resonance (MR) volumetric study in patients with HFS and determined the clinical predictive factors of PF CSF volume. METHODS: Patients with clinically diagnosed HFS and controls matched for age, sex, race, and hypertension underwent MRI/magnetic resonance angiography examination. The PF CSF space was segmented and quantified on a heavily T2-weighted high-resolution 3-dimensional MR volume slab, centered over the porus acusticus. RESULTS: Eighty-two study subjects (41 patients and 41 controls) were included. The mean PF CSF volume in patients with HFS and controls was 17,303.0 ± 3,900.0 vs 19,216.0 ± 3,912.0 mm. The mean volume in patients with HFS was 11.4% smaller than in controls (p = 0.015). Analysis of differences between individually matched pairs and controls also revealed that PF CSF for controls was larger than that for patients with HFS (p = 0.007). A multivariate linear regression analysis revealed that a small PF CSF volume was associated with HFS (p = 0.01). Decreasing age (p = 0.001) and female gender (p < 0.0005), but not hypertension (p = 0.892), were also found to be predictors of a low PF CSF volume. CONCLUSIONS: Our results showed that the posterior fossa (PF) CSF volume was lower in patients with HFS compared with matched controls. HFS, female gender, and younger age were associated with smaller PF CSF volume. These observations could explain the strong female preponderance in both clinic-and population-based epidemiologic studies. Copyright © 2009 by AAN Enterprises, Inc.
Source Title: Neurology
URI: http://scholarbank.nus.edu.sg/handle/10635/110646
ISSN: 00283878
DOI: 10.1212/WNL.0b013e3181b9c8ce
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on Oct 12, 2018

WEB OF SCIENCETM
Citations

20
checked on Oct 3, 2018

Page view(s)

46
checked on Sep 28, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.